Validating the genomic signature of pediatric septic shock dating exclusively but not boyfriend girlfriend
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The challenges moving forward include robust validation studies, standardization of technical approaches, standardization and further development of analytical algorithms, and large-scale collaborations.Over the past decade several investigators have applied microarray technology and related bioinformatic approaches to clinical sepsis and septic shock, thus allowing for an assessment of how, or if, this branch of genomic medicine has meaningfully impacted the sepsis field.This review will first provide an overview of the gene microarray approach, including limitations and study design considerations.Subsequently, the review will focus on the potential translational application of microarray data and genome-wide expression profiling to the sepsis field.Four broad areas will be discussed: genome-level understanding of sepsis, biomarker discovery, gene expression-based identification of septic shock subclasses, and discovery of novel targets and pathways.], that has potentially intriguing applications for the field, but will not be further discussed as there are no RNA-Seq data specifically related to sepsis.